Preservation of large-scale chromatin structure in FISH experiments
نویسندگان
چکیده
منابع مشابه
Large-scale chromatin structure and function.
Recent results in living cells have now established the existence of levels of chromatin folding above the 30 nm fiber within interphase chromosomes. We discuss the potential functional impact of this large-scale chromatin organization, including its possible role in regulating gene expression.
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The estrogen receptor (ER), a member of the nuclear hormone receptor superfamily important in human physiology and disease, recruits coactivators which modify local chromatin structure. Here we describe effects of ER on large-scale chromatin structure as visualized in live cells. We targeted ER to gene-amplified chromosome arms containing large numbers of lac operator sites either directly, thr...
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ژورنال
عنوان ژورنال: Chromosoma
سال: 2006
ISSN: 0009-5915,1432-0886
DOI: 10.1007/s00412-006-0084-2